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Niners quarterback Jimmy Garoppolo is officially out for the season with a torn ACL.
Tom Brady and the Patriots struggle in 26-10 loss to the Lions; Kerryon Johnson: first 100-yard rusher for the Lions since Thanksgiving 2013.
Rams offense puts up over 500 yards as they win the battle for LA against the Chargers, 35-23.
Saints win shootout in Atlanta against the Falcons, 43-37 in overtime.
Josh Allen and the Bills stun the Vikings in Minnesota, 27-6.